Tree nuts playing a mysterious melody? What the heck is that? - Lloyd Irving, Tales of Symphonia

Raine: I wonder what that monster was called...
Colette: I like Poochie!
Raine: No dear, I was referring to the species.
- Tales of Symphonia

Palutena: Bows fit you
Pit: That's why I used it in my last brawl
Palutena: I somehow can't imagine you in a meele
Pit: that's because I wasn't

Kid Icarus: Uprising (roughly reconstructed from my memory, might differ from the actual game)

Can't remember the guys name - "Greetings. I threw the bones!"
Same guy a little later - "What are you still standing around?"

^Those were both translations that failed. Not sure if that counts as game quotes.

From a MMO (Does that count as a game that this topic is referring too?) that nobody has probably ever heard of aside from me.

Left 4 Dead 2:

(The setting. We're in a sewer. Ellis just got incapacitated and has fallen down with his pistol out)

Ellis - "Hey look! I candy bar. Whoops, false alarm.

(At some other random place)

Ellis dies.
Nick walks near Ellis' dead body and says - "I'm surprised he made it as far as he did."

Absolutely no sympathy whatsoever. XD

"Bitch took my skull!" - 50 Cent, 50 Cent: Blood on the Sand

"Riggs had a nice little sleepover set up. Everything needed to nail him was there - a cop's wet dream." - Jack Slate, Dead to Rights: Retribution
^Something is very wrong about that quote uhhhh

"You've got access to the PC of the director of the fucking F B bastard I! Approve the request." - Old Hoxton, PAYDAY 2 (upon someone else hacking the FBI Director's computer)

*Dragan kills a guard*
Pager Guy: "What's going on down there? Pick up the pager or I'll sound the alarm."
Dragan: "Uh, I was wondering...what does the fox say?"
Pager Guy: "Uh huh, yeah, that seems about right... Hold on a second."
*static for 2 seconds*
Pager Guy: "Okay, now you're just taking advantage of me. Next time, I'm sounding the alarm."

^ That last one had me laughing out loud. Oh, man.