Depends on many factors such as if you're soloing or not, you have support etc. If you're playing solo, the monster will probably lock on you. If you have teammates there'll be some moments when it'll focus on them. Also I don't recommend using pierce on diablos or ian. In Theory you can hunt down anything with everything. But of course some weapons work better than others like hammer on ura. I mainly use pierce on Ludroth, P. Ludroth, Lagi, I. Lagi, Jhen, H. Jhen, Gigginox, B. Gigginox, Miralis, Ceaseus, G. Ceaseus. It makes wonders on other monsters too, but you need to have status support.